Both CSS Grid and Flexbox are powerful layout tools, but they serve different purposes. Flexbox is designed for one-dimensional layouts, while CSS Grid is intended for two-dimensional layouts. Understanding these differences is crucial for creating efficient and responsive layouts. Flexbox excels in laying out items in a single direction — either horizontally or vertically. It’s perfect for situations where you need items to align, distribute space, and remain flexible across different screen sizes. Flexbox is often used for simple navigation bars, footer layouts, and small grid-like sections where items are aligned in a row or column. CSS Grid, on the other hand, is more powerful for creating complex grid layouts. It allows you to define both rows and columns and place items within this grid at specific locations. This makes it ideal for dashboard layouts, complex page structures, and when you need both horizontal and vertical control over the layout. While Flexbox is a simpler tool for single-axis alignment, CSS Grid provides unparalleled control for two-dimensional layouts. In many cases, you may even use both together — Flexbox inside a grid item to handle layout on one axis and Grid to manage the overall structure.